Summary
Overview
Work History
Education
Skills
Accomplishments
Additional Information
Software
Publications
Teaching Experience
Administrative Experience
Timeline
Generic
Dr. Zarith Nameyrra Md Nesran

Dr. Zarith Nameyrra Md Nesran

Researcher & Teaching Assistant
Kuala Lumpur

Summary

Biomedical researcher with 10 years of interdisciplinary experience spanning pharmacology, toxicology, cancer biology, medical microbiology, and immunology, complemented by clinical research exposure. Experienced in experimental design, molecular and cellular techniques, antimicrobial resistance research, transcriptomic analysis, and molecular modelling, with a strong peer-reviewed publication record. Familiar with patient-oriented research, including recruitment and biological sample management. Proven educator and mentor with postgraduate and undergraduate teaching experience, including scientific writing and laboratory training. Committed to high-impact research, collaborative scholarship, and research-led teaching.

Overview

12
12
years of professional experience
2
2
Languages

Work History

Research Assistant

Faculty of Medicine, UKM
10.2025 - Current
  • Research Focus: Conducted research on the effects of Gundelia tournefortii L. (GTL) extracts on angiotensin II-induced hypertrophied cardiomyocytes (heart’s muscle tissue).
  • Cell Culture Management: Maintenance of H9C2 cell lines (cardiomyocytes) and conducted MTT assays to determine cytotoxicity in GTL extracts.
  • Antihypertrophic Screening: Measured cell size after the GTL extracts treatment.

Graduate Research Assistant

Faculty of Medicine, UKM
10.2020 - 07.2024
  • Research Focus: Conducted research on gastrointestinal physiological environment, and related GIT-tract (eg: Helicobacter pylori infection), exploring the mechanisms of antimicrobial peptides (AMP) to uncover novel therapeutic solutions for antibiotic resistance.
  • Bacterial Culture Management: Oversaw the preparation, maintenance, and optimization of bacterial cultures, including designing specialized growth media and antibiotics tailored for experimental research.
  • Antimicrobial Testing: Directed the implementation of minimum inhibitory concentration (MIC) assays, evaluating the efficacy of various antimicrobial agents and their potential clinical applications.
  • Molecular Analysis: Performed molecular docking, DNA & RNA extractions, with comprehensive RNA sequencing (RNA- seq) analysis. Identified key pathways, including the activation of the ribosomal pathway, contributing to the understanding of bacterial resistance mechanisms.

Research Officer

National Institute of Health, MOH
04.2023 - 10.2023
  • Evidence Synthesis: Conducted reviews and meta-analyses of global and national data on prostate cancer, cervical cancer, and breast cancer to provide evidence for policy development and interventions.
  • Guidelines Development: Contributed to the development and revision of national health policies and clinical guidelines, ensuring alignment with the latest research and best practices.
  • System Integration: Collaborated with public health authorities to integrate cancer research findings into national health programs, enhancing early detection, treatment protocols, patient care pathways.
  • Knowledge Dissemination: Produced project summary booklets that synthesized research outcomes and policy recommendations, informing healthcare providers, policymakers, and the general public.
  • Stakeholder Engagement: Facilitated workshops, and training sessions for healthcare professionals and policymakers to enhance implementation of evidence-based cancer interventions.

Research Assistant

Hospital Canselor Tuanku Muhriz
02.2019 - 09.2020
  • Primary Research: Conducted extensive studies on ovarian cancer and immunology, with emphasis on the physiological interactions within the tumor microenvironment and the immune system’s response to develop targeted therapeutic approaches.
  • Clinical Collaboration: Coordinated patients’ recruitment and ensured adherence to research ethics applications by working with clinical specialists and staff from HCTM, Hospital Ampang, and IKN.
  • Biological Sampling: Managed the collection, processing, and storage of biological samples, including blood, biopsy tissues, serum, and ascites, ensuring sample integrity for downstream analyses.
  • Technical Expertise: Performed immunohistochemistry and flow cytometry operations to analyze immune cell populations and biomarkers, providing insights into ovarian cancer pathophysiology.

Graduate Research Assistant

Faculty of Medicine & Health Science, UPM
02.2016 - 06.2018
  • Cell Culture: Maintained cell lines (HT-29, HCT116, H1688, H2135, 3T3, ARPE19) to investigate the molecular mechanisms of colorectal cancer and endoplasmic reticulum stress in cancer therapy.
  • Cell Viability: Conducted MTT assays to assess cell proliferation and viability in response to treatments with green tea EGCG and pharmacological agents, helping evaluate potential anti-cancer properties.
  • Western Blot Analysis: Performed Western blotting techniques to analyze protein expression related to the unfolded protein response, endoplasmic reticulum stress, and molecular markers of apoptosis.
  • Caspase 3/7 Assay: Executed Caspase 3/7 activity assays to assess the extent of apoptosis induced by treatments, providing insight into the molecular mechanisms of cell death.

Plant Tissue Culturist

MGEN Propagation Sdn. Bhd.
10.2015 - 12.2015
  • Commercial Plantation: Conducted tissue culture techniques for the propagation of N. Cadamba, optimizing growth conditions for large-scale commercial plantations and ensuring quality production.
  • In Vitro Cultures: Established and maintained in vitro cultures of N. Cadamba using aseptic techniques, promoting rapid multiplication and disease-free plantlets for efficient propagation.
  • Growth Media: Tested and optimized growth media, hormone concentrations, and environmental conditions to enhance the successful regeneration and acclimatization of plantlets for field planting.

Research Assistant

University of Nottingham Malaysia Campus
03.2014 - 06.2015
  • Polyphenols Extraction: Operated High-Performance Liquid Chromatography (HPLC) systems for the analysis of polyphenols, ensuring accurate quantification and identification in various biological samples.
  • Cell Culture & MTS Assay: Cultivated human liver cells (HepG2) and performed MTS assays, evaluating the effects of polyphenols and other compounds in molecular medicine research.

Education

Ph.D. - Medical Microbiology & Immunology

Universiti Kebangsaan Malaysia (UKM)
04.2001 -

Master of Science - Pharmacology & Toxicology

Universiti Putra Malaysia (UPM)
12-2019

BSc. (Hons) - Plant Biotechnology

University of Nottingham
07-2013

Sijil Pelajaran Malaysia (8A) -

MRSM Taiping
12-2007

Skills

  • Analytical research skills
  • Pharmacology & Toxicology
  • Cancer Research
  • Molecular Biology
  • Evidence Synthesis
  • Experimental Design
  • Higher education instruction
  • Scientific Writing
  • Research Collaboration
  • Mentoring intern students
  • Teaching postgraduate students
  • Educational Material Production

Accomplishments

  • Best Oral Presentation

International Symposium on Helicobacter & Upper Gastrointestinal Diseases, Seoul, Korea

  • HUG 2024 Travel Grant

International Symposium on Helicobacter & Upper Gastrointestinal Diseases, Seoul, Korea

  • Scholarship Recipient Awards

Human Life Advancement Foundation (HLAF)

Jameel Education Foundation (JEF), Dubai, UAE

Additional Information

  • Noncommunicable Disease Malaysia Conference, Taylor’s University, Selangor (2025)
  • Program Khidmat Masyarakat ‘Jom Sihat, Bebas Kuman’, Bota, Perak (2024)
  • The 32nd Annual Meeting of the Korean College of Helicobacter & Upper Gastrointestinal Research, Seoul, Korea (2024)
  • Workshop on Molecular Docking and Biomolecular Interactions Using Autodock4, SATREP Malaysia, Japan Laboratory, UNISEL (2022)
  • ASAIHL Conference 2022: Emerging Infectious Disease: A Recurrent Threat to Human Society, UPM (2022)
  • EHMSG Postgraduate Course: The Microbiome Meets the Clinic: Turning Understanding into New Treatments, Glasgow, UK (2022)
  • 35th Workshop of the European Helicobacter and Microbiota Study Group, Glasgow, UK (2022)
  • Molecular Dynamics Simulations Workshop, Swinburne University of Technology Sarawak Campus (2022)
  • 7th ASEAN Flow Cytometry Workshop, UM (2019)
  • Seminar on Lymphedema: Swollen Limbs After Cancer Treatment (2018)
  • 1 Malaysia Young Entrepreneur Challenge (1M-YEC) with MITI & SIFE (2012)

Software

Microsoft Office

SPSS

GraphPad

Minitab

PAST

PyMOL

AutoDock

HADDOCK 24

ViewerLite

RasMol

Publications

  • Md Nesran, Z.N., Shafie, N. H., Mohd Esa, N., & Ismail, A. (2017). Anti-proliferative Effect of Green Tea Epigallocatechin-3-gallate (EGCG) on Colorectal Cancer HT-29 Cell Lines. A Cytotoxicity Analysis. Presented at the PUTRA Cancer Research Symposium 2017 on 5th – 6th September 2017 at Institute of Bioscience,UPM, Serdang, Selangor, Malaysia. (Poster)
  • Md Nesran, Z.N., Shafie, N. H., Mohd Esa, N., & Ismail, A. (2018). The induction of ER stress by green tea epigallocatechin-3-gallate (EGCG) in the colorectal cancer line HT-29. Presented at the 2rd AMDI International Biohealth SciencesConference (IBSC) 2018: 1st International Symposium on Herbal Medicine on 18th – 20th January 2018 at Riverside Majestic Hotel, Kuching, Sarawak, Malaysia. (Oral)
  • Md Nesran, Z.N., Shafie, N. H., Mohd Esa, N., & Ismail, A. (2018). The Potential of Green Tea Epigallocatechin-3-gallate (EGCG) in Targeting Endoplasmic Reticulum (ER) Stress Pathway in Colorectal Cancer. Presented at the Bromo Conference: Symposium on Natural Products and Biodiversity on 11th – 12th July 2018 at Universitas Airlangga, Surabaya, Indonesia. (Poster)
  • Md Nesran, Z.N., Shafie, N. H., Mohd Esa, N., & Ismail, A. (2019). Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α. BioMed Research International, 2019, 3480569. doi:10.1155/2019/3480569 | 48 citations (Q1)
  • Md Nesran, Z.N., Shafie, N. H., Mohd Esa, N., & Ismail, A. (2020). Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking. Evidence-based Complementary and Alternative Medicine, 2020, 7958041. doi:10.1155/2020/7958041 | 32 citations (Q2)
  • Lopes, B.S., Hanafiah, A., Nachimuthu, R., Muthupandian, S., Md Nesran, Z.N., & Patil, S. (2022). The Role of Antimicrobial Peptides as Antimicrobial and Antibiofilm Agents in Tackling the Silent Pandemic of Antimicrobial Resistance. Molecules. 2022;27(9):2995. doi:10.3390/molecules27092995 | 70 citations (Q2)
  • Sukri A, Hanafiah A, Yusoff H, et al. (2022). Multidrug-Resistant Helicobacter Pylori Strains: A Five- Year Surveillance Study and Its Genome Characteristics. Antibiotics. 2022;11(10):1391. doi:10.3390/antibiotics11101391 | 20 citations (Q2)
  • Md Nesran, Z.N., Ahmad, M.F., Abd Aziz S.N.A., & Hanafiah, A. (2024). Investigating LL-37 Interaction with H. pylori: Molecular Complexes and Antimicrobial Resistance. The 32nd Annual Meeting of the Korean College of Helicobacter and Upper Gastrointestinal Research. 2024. page 59. (Oral – Best Presentation Award)
  • Hanafiah, A., Abd Aziz, S.N.A., Md Nesran, Z.N., Wezen, X.C., & Ahmad, M.F. (2024). Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach. Heliyon. 2024 Mar 17;10(6):e28128. doi: 10.1016/j.heliyon.2024.e28128. PMID: 38533069; PMCID: PMC10963377 | 3 citations (Q1)
  • Ang, Z.Y., Kong, Y.L., Md Nesran, Z.N., & Lee, W.S.H. (2024). Efficacy of decision aid delivery modes in prostate cancer screening: umbrella review and network meta-analysis. BJU International, 2024; doi: 10.1111/bju.16545. | 1 citation (Q1)
  • Md Nesran, Z.N., Hanafiah, A., Sukri, A., Mohd Fahami, N.A., Raja Ali, R.A. & Lopes, B.S. (2025). Transcriptomic and Molecular Insights into the Response of Multidrug-Resistant Helicobacter pylori to Human Neutrophil Peptide 1 (HNP-1). Probiotics Antimicrob Proteins, 2025; doi: 10.1007/s12602-025-10747-4. | 1 citation (Q1)

Teaching Experience

  • Teaching Assistant and Laboratory Demonstrator
  • Taught and guided postgraduate, undergraduate, final year project (FYP) students, and practical groups in laboratory and lecture settings.
  • Provided hands-on training in laboratory techniques and research methods, fostering student comprehension and engagement.
  • Evaluated and marked undergraduate examination papers, maintaining consistency and fairness in grading standards.
  • Delivered one-on-one tutoring and group classes across all school levels, tailoring lessons to individual student needs.
  • Demonstrated excellent subject matter expertise and communication skills to enhance students' academic performance.

Administrative Experience

  • Experienced in ordering and purchasing laboratory items, managing research grants, and preparing ethics applications.
  • Proficient in drafting formal documents, including letters, protocols, proposals, reports, and administrative correspondence.

Timeline

Research Assistant

Faculty of Medicine, UKM
10.2025 - Current

Research Officer

National Institute of Health, MOH
04.2023 - 10.2023

Graduate Research Assistant

Faculty of Medicine, UKM
10.2020 - 07.2024

Research Assistant

Hospital Canselor Tuanku Muhriz
02.2019 - 09.2020

Graduate Research Assistant

Faculty of Medicine & Health Science, UPM
02.2016 - 06.2018

Plant Tissue Culturist

MGEN Propagation Sdn. Bhd.
10.2015 - 12.2015

Research Assistant

University of Nottingham Malaysia Campus
03.2014 - 06.2015

Ph.D. - Medical Microbiology & Immunology

Universiti Kebangsaan Malaysia (UKM)
04.2001 -

Master of Science - Pharmacology & Toxicology

Universiti Putra Malaysia (UPM)

BSc. (Hons) - Plant Biotechnology

University of Nottingham

Sijil Pelajaran Malaysia (8A) -

MRSM Taiping
Dr. Zarith Nameyrra Md NesranResearcher & Teaching Assistant